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Preconception Testing: Lab Work Before Pregnancy

By the EllaDx team · Updated December 16, 2025 · 1 min read

For education only, not a diagnosis. Talk to your clinician about your results.

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The best time to optimize your health for pregnancy is before you conceive. Preconception testing helps identify and address issues that could affect fertility or pregnancy.

Why Preconception Testing Matters

  • Identify nutritional deficiencies
  • Optimize thyroid function
  • Screen for infections
  • Assess metabolic health
  • Address hormonal imbalances

The Preconception Lab Panel

Thyroid

  • TSH (optimal <2.5 for pregnancy)
  • Free T4, Free T3
  • Thyroid antibodies

Nutrients

  • Vitamin D (aim for 40-60 ng/mL)
  • Vitamin B12 (optimal >500 pg/mL)
  • Folate (or MTHFR testing)
  • Ferritin (optimal >50 ng/mL)
  • Iron panel

Metabolic

  • Fasting glucose and HbA1c
  • Fasting insulin
  • Lipid panel

Infections

  • Rubella immunity
  • Varicella immunity
  • Hepatitis B
  • HIV (recommended by ACOG)

Reproductive

  • Blood type and Rh factor
  • Genetic carrier screening (optional)

Optimizing Before Pregnancy

Address any deficiencies or imbalances before trying to conceive:

  • Start prenatal vitamins 3 months before
  • Optimize thyroid function
  • Achieve healthy ferritin levels
  • Stabilize blood sugar
  • Manage any autoimmune conditions

References

  • American College of Obstetricians and Gynecologists. (2019). ACOG Committee Opinion No. 762: Prepregnancy counseling. Obstetrics & Gynecology, 133(1), e78-e89.
  • Dean, S. V., et al. (2014). Preconception care: nutritional risks and interventions. PLoS Medicine, 11(3), e1001607.